Status:
RECRUITING
Multifaceted Comparison of Ultrasound-guided Ablation and Laparoscopic Adrenalectomy for Aldosterone-producing Adenoma
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Aldosterone-producing Adenoma
Radiofrequency Ablation
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to retrospectively and prospectively analyze the efficacy and safety of ultrasound-guided radiofrequency ablation and laparoscopic adrenalectomy in the treatment of aldost...
Detailed Description
Primary aldosteronism is the most common cause of secondary hypertension, and aldosterone-producing adenoma (APA) is a benign adrenal tumor, accounting for about 35% of primary aldosteronism. Accordin...
Eligibility Criteria
Inclusion
- APA was confirmed with unilateral lesions;
- Benign tumor without adrenal metastasis and endovascular tumor embolus;
- Receive ultrasound-guided adrenal RFA treatment or laparoscopic resection, and sign the informed consent for surgery;
- Age ≥ 18;
- Age ≥ 40 years old should meet the following criteria: blood potassium ≤3.5mmol/L; PAC≥20ng/dL; PRC≤5μIU/mL; A unilateral adrenal nodule of 10mm or more was completely normal on the opposite side.
Exclusion
- Bilateral adrenal diseases;
- Multiple adrenal tumors;
- Other adrenal diseases, such as adrenal hyperplasia, Cushing's syndrome, pheochromocytoma, etc.;
- Imaging suggests that the tumor may be difficult to reach;
- Imaging showed potential malignant adrenal tumor;
- Pregnant and/or planning a pregnancy;
- Refusing to participate in follow-up visits.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05991856
Start Date
January 1 2020
End Date
December 1 2030
Last Update
August 15 2023
Active Locations (1)
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1
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510000