Status:
COMPLETED
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Lead Sponsor:
Université de Sherbrooke
Collaborating Sponsors:
Association Pulmonaire du Quebec
Réseau de Recherche en Santé Respiratoire du Québec
Conditions:
Asthma
Asthma in Children
Eligibility:
All Genders
18+ years
Brief Summary
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic diseas...
Detailed Description
BACKGROUND Asthma affects 10% of the general population but remains a diagnostic challenge. Considering the difficult access, weak specificity, and low clinical utility of bronchial provocation tests,...
Eligibility Criteria
Inclusion
- aged ≥ 12 years who have symptoms suggestive of asthma,
- referred by their primary care provider (defined as a non-respirologist, non-allergist, non-otolaryngologist) using the CHUS suspected asthma decision-making algorithm. Under that algorithm, patients have non-diagnostic pre- and post-bronchodilator spirometry and no contraindications to a methacholine challenge.
- Free and informed consent must be given by the patient (and their legal guardian, if applicable).
Exclusion
- Use of an inhaled or systemic corticosteroid in the previous 48 hours;
- Smoking in the previous 6 hours; history of viral and/or bacterial respiratory infection in the past 4 weeks;
- major cardiopulmonary disease, including: a) chronic obstructive pulmonary disease (COPD), defined by all of the following: i) aged ≥ 40 years , ii) permanent obstruction on spirometry (FEV1/FVC \<0.7) and iii) a smoking history of \>10 pack-years or known alpha-1-antitrypsin deficiency, b) lung conditions deemed significant by the investigator, including cystic fibrosis and bronchiectasis, and c) unstable heart disease.
Key Trial Info
Start Date :
November 7 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2025
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT05992519
Start Date
November 7 2022
End Date
October 31 2025
Last Update
November 19 2025
Active Locations (1)
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1
Centre de Recherche du CHUS
Sherbrooke, Quebec, Canada, J1H5N4