Status:
COMPLETED
Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study
Lead Sponsor:
Tanta University
Conditions:
Small Fiber Neuropathy
Diabetic Neuropathies
Eligibility:
All Genders
18+ years
Brief Summary
The aim of work is to study the clinical, electrodiagnostic and neurosonographic characteristics of diabetic patients with small fiber neuropathy in the Egyptian population, and to evaluate both the d...
Detailed Description
This case-control observational study is aiming to evaluate patients with diabetic small fiber neuropathy in the Egyptian. Diabetic small fiber neuropathy was defined as both of the following: A. Ty...
Eligibility Criteria
Inclusion
- Patients diagnosed with diabetes mellitus or impaired glucose intolerance by laboratory investigations including any of the following: HbA1C, fasting blood sugar and 2-hour post prandial blood sugar, and/or antidiabetic medication.
- Patients presented with small fiber neuropathy (SFN), including all the following:
- A. Typical clinical symptoms of SFN such as burning or sharp pain in toes and feet, and on clinical examination: loss of small fiber modalities (pinprick and temperature), hyperalgesia, allodynia, and/or autonomic signs.
- B. Reduced intraepidermal nerve fiber density (IENFD) in distal leg skin punch biopsy.
- Age older than 18 years old
Exclusion
- Mental illness that made interviewing ineffective
- Physical illness leading to language and/or cognitive barrier
- Other conditions that could cause neuropathy (e.g., chemotherapy, alcohol intake, established vitamin B12 deficiency, established hereditary neuropathy "or first-degree family members", active malignancy, chronic advanced liver or kidney diseases thought to cause neuropathy and history of bariatric surgery).
- Atrial Fibrillation
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 22 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05993871
Start Date
January 1 2023
End Date
January 22 2024
Last Update
April 10 2024
Active Locations (1)
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1
Ahmed Sami Mahmoud Alkotami
Kafr ash Shaykh, Egypt, 33511