Status:
ACTIVE_NOT_RECRUITING
Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Cervical Neoplasm
Adaptive Radiotherapy
Eligibility:
FEMALE
18-70 years
Phase:
NA
Brief Summary
External radiation given in 25 fractions or so together with weekly chemotherapy and followed by 5 or 6 fractions of brachytherapy is the standard of care for patients with locally advanced cervical c...
Detailed Description
This is an investigator-initiated efficacious, single-center, open-label clinical trial study. This study hypothesizes that the use of external moderately hypofractionated radiotherapy of cervical can...
Eligibility Criteria
Inclusion
- Age 18 years to 70 years
- FIGO Stage IB1, IB2, IB3, IIA or IIB cervical cancers
- FIGO stage IIIC1 cervical cancers are candidates but must meet all the following criteria:largest node is less than 1.5 cm,less than 3 pathological nodes,No nodes located in the common iliac chain
- Histology: squamous
- Candidate for definitive chemoradiotherapy to be delivered with weekly cisplatin
- Brachytherapy candidate
- Functional State Eastern Cooperative Oncology Group (ECOG)0-2
Exclusion
- Patients who had chemotherapeutic, surgical and/or radiotherapy treatment
- FIGO stage IIIA, IIIB, IIIC2, IVA or IVB
- FIGO stage IIIC1 with node greater than 1.5 cm, common iliac node or greater than 2 pathological nodes
- Previous pelvic or abdominal radiotherapy
- Patient unable to undergo MR scan
- ECOG performance status greater than 2
- Not a cisplatin candidate
- Other factors that contraindicate experimental therapy
Key Trial Info
Start Date :
September 19 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05994300
Start Date
September 19 2023
End Date
December 31 2025
Last Update
June 8 2025
Active Locations (1)
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1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100010