Status:
UNKNOWN
The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis
Lead Sponsor:
Ali A Abdulkareem
Conditions:
Periodontal Disease, AVDC Stage 3and 4
Epithelial Mesenchymal Transition
Eligibility:
All Genders
Brief Summary
Periodontitis is a polymicrobial, inflammatory condition affecting tooth-supporting tissues. It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone, which c...
Eligibility Criteria
Inclusion
- Patients with no history of systemic disease e.g., diabetes.
- Both males and females will be included in the study.
- Control group: patients fit the case definition of gingival health2, and confirmed by Histopathological inflammatory cell infiltration analysis.
- Periodontitis group: patients fit the case definition of periodontal disease referred for periodontal flap surgery (modified Widman's flap).
- Patients radiographically confirmed with infrabony pocket eligible for periodontal flap surgery.
Exclusion
- Patients not willing to participate or consent.
- Patient taking medications that affect or modify immunity (e.g., corticosteroid), for the last 3 months.
- Patient taking NSAIDs for the last 3 months.
- Active smoker.
Key Trial Info
Start Date :
February 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 30 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05995067
Start Date
February 14 2022
End Date
January 30 2024
Last Update
December 12 2023
Active Locations (1)
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1
saif mohammed T AL Mufti
Baghdad, Iraq, 964