Status:
COMPLETED
A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age
Lead Sponsor:
ModernaTX, Inc.
Conditions:
Smallpox
Mpox
Eligibility:
All Genders
18-49 years
Phase:
PHASE1
PHASE2
Brief Summary
The goal of this study is to assess the safety, tolerability and immunogenicity of mRNA-1769 in healthy adult participants.
Eligibility Criteria
Inclusion
- Has a body mass index (BMI) between ≥18 kilogram per square meter (kg/m\^2) to ≤39 kg/m\^2.
- For female participants of childbearing potential: must have a negative highly sensitive pregnancy test with 28 days before the first dose of study drug, uses approved contraception during the study intervention period and for at least 3 months after the last dose of study drug, and not currently breastfeeding.
Exclusion
- History of smallpox vaccination, vaccination with any poxvirus-based vaccine, history of of/or recent exposure to Mpox (MPX) (defined as close contact with a confirmed case of MPX within the past 14 days).
- Participant should not have any significant, progressive, unstable, or uncontrolled clinical condition, including any condition that may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures per Investigator judgement.
- Participant is undergoing investigations for a potential chronic medical disorder.
- Bleeding disorder considered a contraindication to IM injection or phlebotomy.
- Dermatologic conditions that could affect local solicited AR assessments.
- History of anaphylactic reaction or allergic reactions that required medical intervention following any vaccine.
- Known or suspected allergy to any component of mRNA-1769.
- History of malignancy within previous 10 years (excluding non-melanoma skin cancer).
- Participant has any medical, psychiatric, or occupational condition, including reported history of drug or alcohol abuse, that, in the opinion of the Investigator, might pose additional risk due to participation in the study or could interfere with the interpretation of study results.
- Participant has received systemic immunosuppressants or immune-modifying drugs for \>14 days in total within 6 months prior to Screening (for corticosteroids, ≥10 mg/day of prednisone or equivalent) or is anticipating the need for immunosuppressive treatment at any time during participation in the study. Topical tacrolimus is allowed if not used within 14 days prior to the day of enrolment. Participants may be rescheduled for enrolment if they no longer meet this criterion within the Screening Period. Inhaled, nasal, and topical steroids are allowed.
- Receipt or planned receipt of: Any vaccine(s), authorised or approved by local health agency, including mRNA vaccine, ≤28 days prior to the first injection through 28 days after the last dose of investigational (IMP).
- Intravenous blood products (red cells, platelets, immunoglobulins) within 3 months prior to the first injection up to the end of the study.
- Participated in an interventional study/received an investigational product within 28 days prior to the Screening Period or plans to do so while enroled in this study.
- Note: Other inclusion and exclusion criteria may apply.
Key Trial Info
Start Date :
August 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 8 2025
Estimated Enrollment :
351 Patients enrolled
Trial Details
Trial ID
NCT05995275
Start Date
August 15 2023
End Date
July 8 2025
Last Update
July 16 2025
Active Locations (12)
Enter a location and click search to find clinical trials sorted by distance.
1
Bradford Teaching Hospitals NHS Foundation Trust
Bradford, United Kingdom, BD9 6RJ
2
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, United Kingdom, BS2 8DX
3
Lakeside Healthcare Research
Corby, United Kingdom, NN17 2UR
4
University Hospitals of Leicester
Leicester, United Kingdom, LE1 5WW