Status:
RECRUITING
CEST in Low-grade Glioma Study
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Low-grade Glioma
Eligibility:
All Genders
12+ years
Phase:
NA
Brief Summary
Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Trans...
Detailed Description
Please see trial details below:
Eligibility Criteria
Inclusion
- Be at least 12 years of age;
- Diagnosed with:
- Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or
- Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
- No contraindications to MRI;
- eGFR \> 30 ml/min;
- No prior chemotherapy or radiation therapy;
- No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy)
- Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital
Exclusion
- Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy
- Pregnancy
Key Trial Info
Start Date :
August 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 12 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05996653
Start Date
August 12 2022
End Date
August 12 2028
Last Update
August 18 2023
Active Locations (2)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
2
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8