Status:
RECRUITING
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Lead Sponsor:
Stanford University
Collaborating Sponsors:
University of Iowa
Massachusetts General Hospital
Conditions:
Major Depressive Disorder
Epilepsy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers wh...
Detailed Description
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder, but remission rates are 20-40%, and ideal stimulation parameters are unknown. rTMS is thoug...
Eligibility Criteria
Inclusion
- Men and women, ages 18 to 65
- Medication-refractory epilepsy requiring phase II monitoring
- Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
- No current or history of major neurological disorders other than epilepsy
Exclusion
- Those with a contraindication for MRIs (e.g. implanted metal)
- Any unstable medical condition
- Neurological or uncontrolled medical disease
- Active substance abuse
- Currently pregnant or breastfeeding
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT05996900
Start Date
September 1 2023
End Date
July 1 2028
Last Update
November 4 2025
Active Locations (1)
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1
Stanford University
Stanford, California, United States, 94305