Status:
ACTIVE_NOT_RECRUITING
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Lead Sponsor:
University of Nottingham
Conditions:
Skeletal Muscle Atrophy
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence. Undesirable loss o...
Detailed Description
The contraction of skeletal muscles depends on the regulation of the nervous system and the coordination of neuromuscular function. The smallest motor nervous system associated with muscle contraction...
Eligibility Criteria
Inclusion
- Aged 60-85 y
- Willing and able to give informed consent for participation in the study
Exclusion
- BMI \<18.5 or \>35kg/m2
- Participation in any regular, structured RET within the past 6 months
- Musculoskeletal disorders
- Severe respiratory disease:
- COPD
- Pulmonary hypertension
- Neurological disorders:
- Cerebrovascular disease (cerebral haemorrhage; cerebral ischemic stroke)
- Intracranial space-occupying lesion
- Epilepsy
- Metabolic disease:
- Hyper and hypo parathyroidism
- Untreated hyper and hypothyroidism
- Cushing's disease
- Type 1 or 2 diabetes
- Active cardiovascular problems:
- Uncontrolled hypertension (BP\>160/100mmHg)
- Recent cardiac event
- Heart failure (Class III/IV)
- Arrhythmia
- Angina
- Blood clotting disorders
- Active inflammatory bowel or renal disease
- Recent malignancy (in previous 3 years)
- Recent steroid treatment within 6 months or hormone replacement therapy
- Family history of early (\<55yrs) death from cardiovascular disease
- Known sensitivity to Sonovue
Key Trial Info
Start Date :
May 22 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 28 2025
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05997095
Start Date
May 22 2023
End Date
December 28 2025
Last Update
May 2 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2RD