Status:
UNKNOWN
Three Regimens of Ketamine Infusion in Complex Regional Pain Syndrome
Lead Sponsor:
Tanta University
Conditions:
Ketamine Infusion
Complex Regional Pain Syndromes
Eligibility:
All Genders
21-40 years
Phase:
PHASE4
Brief Summary
To evaluate the efficacy of three regimens of sub anesthetic dose of ketamine infusion in relieving chronic refractory pain in patients with complex regional pain syndrome
Detailed Description
Ketamine N-methyl-D-aspartate (NMDA) receptor blocker that has recently been studied for its analgesic effect is a phencyclidine or phenyl cyclohexyl piperidine (PCP) derivative that initially became ...
Eligibility Criteria
Inclusion
- Patients aged more than 21 years old of both sexes with American Standards Association I ,II.
- Patients diagnosed as ( CRPS) based on Budapest criteria
- The average daily pain intensity required on (NRS) is 7 or more for at least 3 months despite of standard therapy which includes: (pharmacologic therapy as non steroidal anti- inflammatory drugs (NSAIDs), antiepileptic (AEDs), antidepressants), as well as physical therapy and psychiatric care
Exclusion
- patients refusal
- Patients with unstable psychological or psychiatric conditions, including : untreated bipolar disorder, post-traumatic stress disorder, major depression , severe personality disorder and psychotic illness.
- Patients have recently undergone major interventional pain procedures, such as nerve blocks or implantable therapies within 3 months of enrollment.
- Patients with known drug dependency or substance use disorder specifically related to ketamine or other psycho-stimulant drugs.
- Patients with previous severe reactions, contraindication or allergy to ketamine.
- Patients with cardiovascular disease (hypertension, arrhythmia), hepatic, renal or other organ impairment.
Key Trial Info
Start Date :
August 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2024
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT05997134
Start Date
August 30 2023
End Date
September 1 2024
Last Update
August 31 2023
Active Locations (1)
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1
Tanta University
Tanta, El-garbia, Egypt, 31527