Status:
COMPLETED
Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy
Lead Sponsor:
Mansoura University
Conditions:
Postoperative Nausea and Vomiting
Postoperative Pain
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Since the peak effect of the dexamethasone is delayed to 12-16 hours after iv administration, we designed this study to investigate the effect of administering dexamethasone at-night before surgery ve...
Detailed Description
Background: Postoperative nausea and vomiting (PONV) are common complications after laparoscopic cholecystectomy. The aim of this study is to evaluate the efficacy of administration of prophylactic d...
Eligibility Criteria
Inclusion
- all consecutive adults (older than 18 years) with ASA physical status I-III undergoing elective laparoscopic cholecystectomy surgery at gastrointestinal surgery center.
Exclusion
- patient refusal
- use of steroids or antiemetic agents within 1 week of surgery
- chronic opioid therapy
- history of allergy to any study medications
- serum creatinine \> 1.4 mg/dl
- liver enzymes more than triple normal limits
- pregnancy
- psychiatric or neurologic diseases or socioeconomic status that would hinder postoperative quality of recovery questionnaire
- Patients whose laparoscopic surgery is converted to open surgery after enrollment will be excluded.
Key Trial Info
Start Date :
October 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05998317
Start Date
October 8 2023
End Date
November 20 2023
Last Update
January 25 2024
Active Locations (1)
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1
Faculty of Medicine
Al Mansurah, Aldakahlia, Egypt, 35516