Status:
TERMINATED
NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients
Lead Sponsor:
University of California, San Francisco
Conditions:
Acute Kidney Injury
Cirrhosis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this pilot, randomized, single-blind clinical trial is to estimate the effect size of a high and low mean arterial pressure (MAP)-target algorithm among cirrhosis patients hospitalized wit...
Eligibility Criteria
Inclusion
- Hospitalized patients with decompensated cirrhosis, defined as a Child-Pugh Score ≥ 7
- Acute Kidney Injury: a ≥50% increase in sCr from an outpatient baseline sCr measured 7 to 365 days prior to admission
Exclusion
- Patients without a baseline (7 - 365 days prior to AKI development) sCr measurement;
- Patients who are already on kidney replacement therapy (KRT) at the time of enrollment;
- Patients with an oxygen requirement greater than 6L via nasal cannula;
- Patients with a serum creatinine level exceeding 5 mg/dL.
Key Trial Info
Start Date :
February 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT06000748
Start Date
February 1 2024
End Date
July 31 2024
Last Update
May 15 2025
Active Locations (1)
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1
University of California San Francisco
San Francisco, California, United States, 94143