Status:
RECRUITING
Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE
Lead Sponsor:
The Hong Kong Polytechnic University
Collaborating Sponsors:
University of Waterloo
The University of Hong Kong
Conditions:
Glaucoma
Visual Impairment
Eligibility:
All Genders
55-80 years
Phase:
NA
Brief Summary
Falls are one of the most serious public health concerns for seniors, with significant medical and economic consequences. This concern is even higher in patients with peripheral field loss due to glau...
Detailed Description
A prospective, 2-arm, randomized, single-blind, active-control trial will enroll 56 moderately- to severely-affected glaucoma patients with stable peripheral field loss, intact cognitive function, and...
Eligibility Criteria
Inclusion
- Presence of moderate to severe bilateral glaucomatous optic neuropathy (GON) from primary open-angle (including normal tension) or angle-closure glaucoma, as determined by an ophthalmologist, with abnormal Glaucoma Hemifield Test on standard Humphrey Field Analyzer 24-2 testing and matching nerve-fiber layer thinning on optical coherence tomography;
- Stable vision and visual field loss for at least 3 months;
- With a best-corrected distance acuity of 6/12 or better (equivalent to 0.3 logMAR acuity or better to confirm that participant's central vision is preserved);
- With a cognitive functional score of 22 or above in the Montreal Cognitive Assessment - Hong Kong version (to confirm participants' intact cognitive function).
Exclusion
- Advanced glaucoma with GON of median deviation worse than -25 decibel;
- Ocular diseases other than glaucoma (e.g., age-related macular degeneration, diabetic retinopathy, and moderate to severe cataract);
- Severe medical problems (e.g., stroke, Parkinson's disease) or self-reported neurological (e.g. brain surgery, brain tumor and peripheral neuropathy), or cognitive disorders (e.g., diagnosed dementia or cognitive impairment);
- Physical impairments (e.g. need the use of orthopedic and mobility aids) or physical limitations restricting them from independent walking;
- Self-reported or medically diagnosed vestibular/ cerebellar dysfunction, history of vertigo, or severe hearing loss;
- Using any medications for any neurological conditions or psychiatric drugs (e.g. sedative, hypnotic) that might interfere motor control; and
- Currently attending any intensive physical/balance training.
Key Trial Info
Start Date :
September 9 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06000865
Start Date
September 9 2023
End Date
December 30 2025
Last Update
July 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000