Status:
RECRUITING
Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections
Lead Sponsor:
University of California, Irvine
Conditions:
Necrotizing Soft Tissue Infection
Eligibility:
All Genders
18+ years
Brief Summary
Necrotizing soft tissue infection (NSTI) is a devastating disease that results in a high rate of in-hospital complications and despite advances in critical care, wound care, and early intervention, NS...
Detailed Description
The objective of this study is to evaluate the safety of a shorter course of antibiotics hypothesizing that a short duration of antibiotics for 48-hours after source-control is achieved will have simi...
Eligibility Criteria
Inclusion
- Adult patients 18 years of age or older with all following criteria:
- Presenting to the Emergency Department with history, exam and/or imaging concerning NSTI, AND
- Patients who undergo consultation by the Emergency General Surgery service, AND
- Patients included must have skin or soft tissue findings consistent with NSTI (erythema, crepitus, or pain out of proportion to exam), AND
- Systemic signs of infection including fever (temperature \>38.0°C) or leukocytosis (≥11,000 peripheral white cells per cubic millimeter), AND
- Patients who undergo excisional debridement and/or amputation to achieve source control.
Exclusion
- Pregnant patients
- Prisoners
- Patients with bacteremia upon admission
- Patients unable to provide consent (including no legally authorized representative)
Key Trial Info
Start Date :
December 28 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06002607
Start Date
December 28 2023
End Date
December 1 2025
Last Update
February 4 2025
Active Locations (1)
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1
University of California Irvine Medical Center
Orange, California, United States, 92868