Status:
COMPLETED
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Lead Sponsor:
Peking University First Hospital
Conditions:
Liver Cancer
Radiofrequency Ablation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Percutaneous radiofrequency ablation is a commonly treatment for patients with liver cancer that cannot be surgically resected. During the procedure, patients need to keep awake and cooperate with the...
Detailed Description
Ultrasound-guided percutaneous radiofrequency ablation is a new technique to treat liver cancer. Under ultrasound guidance, a radiofrequency electrode needle is inserted into the cancer through which ...
Eligibility Criteria
Inclusion
- Aged ≥18 years but ≤85 years.
- Scheduled for elective ultrasound-guided percutaneous radiofrequency ablation for primary or metastatic liver cancer.
Exclusion
- Refused to participate.
- Diagnosed schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery.
- Preoperative left ventricular ejection fraction (LVEF) \<30%, or those with sick sinus syndrome, sinus bradycardia (heart rate \<50 beats per minute), or atrioventricular block at grade II or above without pacemaker.
- Diagnosed obstructive sleep apnea (OSA) or judged to be at high-risk of moderate-to-severe OSA before surgery.
- Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (dialysis before surgery), or classified as American Society of Anesthesiologists (ASA) grade \>III before surgery.
- Inability to communicate due to coma, severe dementia, or language barrier before surgery.
- Allergy to any drug used during the study, or other conditions that are considered unsuitable for study participation.
Key Trial Info
Start Date :
October 16 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 28 2024
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT06003218
Start Date
October 16 2023
End Date
September 28 2024
Last Update
April 2 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034