Status:
RECRUITING
Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
Agency for Healthcare Research and Quality (AHRQ)
Conditions:
Surgical Prophylaxis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The goal of this clinical study is to compare the dosing of an antibiotic in overweight patients having surgery. The main question\[s\] it aims to answer are: * Are the antibiotic concentrations in b...
Detailed Description
The risk of surgical site infections are higher in patients with obesity compared to non-obese adults. Our group has previously demonstrated that radiologic measures of abdominal subcutaneous fat are ...
Eligibility Criteria
Inclusion
- Accessible abdominal computed tomography scan prior to surgery
- Adult patients \> 18 years of age
- Body Mass Index ≥ 25 kg/m\^2
- Expected to receive cefazolin prior to surgical incision
- Estimated creatinine clearance ≥90 mL/min
Exclusion
- History of a hypersensitivity reaction to penicillin or cephalosporin
- Pregnancy
Key Trial Info
Start Date :
March 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT06005168
Start Date
March 8 2023
End Date
September 1 2025
Last Update
December 20 2024
Active Locations (1)
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1
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48108