Status:
UNKNOWN
Vaginal Progesterone Improves Clinical Outcomes of RIF Patients
Lead Sponsor:
Nanjing University
Conditions:
Infertility, Female
Eligibility:
FEMALE
20-40 years
Phase:
NA
Brief Summary
This study is a single-center, randomized, controlled prospective study. Those patients with repeated implantation failure (RIF) who will recieve frozen thawed embryo transfer (FET) are enrolled in th...
Detailed Description
According to the enrollment and exclusion criteria, the patients were enrolled, and the subjects were randomly divided into two groups by computer randomization. Group A was the vaginal progesterone a...
Eligibility Criteria
Inclusion
- Aged between 20 and 40 years old;
- BMI: 18-28 kg/m2；
- Consistent with the diagnosis of repeated implantation failure of unknown reasons, the previous embryo transfer situation meets one of the following:
- Total embryos transferred ≥ 4 high-quality cleavage-stage embryos; ≥ 2 blastocysts; ≥ 2 high quality cleavage-stage embryos +≥ 1 blastocysts;
- At least 1 high-quality embryo remained for embryo transfer;
- Volunteer to participate in the study and sign the informed consent form.
Exclusion
- Patients with recurrent pregnancy loss (≥ 2 biochemical pregnancies or ≥ 2 spontaneous abortions);
- Adverse pregnancy history (stillbirth, fetal malformation, etc.);
- Severe paternal factors: need for TESA or PESA;
- PGT;
- Failure of embryo implantation due to any definite reason, including but not limited to: endometrial adhesion (moderate to severe), thin endometrium (\<7 mm before transformation), endometritis, endometriosis (medium or severe), adenomyosis, untreated hydrosalpinx, hysteromyoma (submucosal fibroids, non submucosal fibroids \> 4.0 cm and/or endometrial compression), reproductive malformation, serious immune disease, serious coagulation function abnormality;
- Chromosome abnormality of either spouse;
- Those with contraindications to pregnancy or assisted reproductive technology.
Key Trial Info
Start Date :
August 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT06005207
Start Date
August 1 2023
End Date
December 31 2025
Last Update
August 22 2023
Active Locations (1)
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1
Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China, 210008