Status:
RECRUITING
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation
The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glympha...
Detailed Description
In this prospective randomized controlled study, 48 patients with communicating hydrocephalus will be enrolled in the study and these patients will be divided into 3 groups in which intervention group...
Eligibility Criteria
Inclusion
- patients with communicating hydrocephalus for elective VP shunt surgery under general anesthesia
- age\> 60 y/o
- conscious clear
- fluency in Chinese
- anticipated hospital stay ≥ 3 days after surgery
Exclusion
- unstable preoperative condition (unstable angina, CHF, asthma attack) within 4 weeks before surgery,
- severe hepatic dysfunction or renal failure
- history of neuropsychological diseases such as schizophrenia, Parkinson's disease, dementia, stroke,
- pre-op cognitive impairment,
- preoperative delirium,
- preoperative depression,
- allergy to contrast medium of MRI.
Key Trial Info
Start Date :
July 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06005363
Start Date
July 1 2023
End Date
June 30 2026
Last Update
August 22 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Linkou Chang Gung Memorial Hospital
Taoyuan District, Taiwan, 33305