Status:
COMPLETED
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Regional Anesthesia Morbidity
Pain, Acute
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase...
Detailed Description
This is a prospective, randomized study in healthy volunteers who will undergo sensory testing using quantitative sensory testing (QST), complete psychosocial and pain questionnaires, and ultrasound-g...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old, ≤ 65 years old
- BMI \>18, \< 35
- Able to speak and understand English
- Willingness to undergo psychophysical testing (e.g., QST, pain questionnaires)
- Willingness to have nerve block performed
Exclusion
- Ongoing acute or chronic pain in upper extremities
- Skin or tissue infection affecting upper extremities
- Previous hypersensitivity to mepivacaine or lidocaine
- Previous neuropathy (numbness, paresthesia, or motor weakness) in either upper extremity
- Loss of any limb
- Bleeding issues or bleeding disorder
- History of alcohol or drug abuse
- Currently pregnant or breastfeeding
- History of seizure or epilepsy
Key Trial Info
Start Date :
September 28 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 28 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06005480
Start Date
September 28 2023
End Date
May 28 2024
Last Update
November 5 2025
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115