Status:
ACTIVE_NOT_RECRUITING
Aerobe Cycling Training in Women With Unexplained Recurrent Pregnancy Loss
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Maastricht University Medical Center
Conditions:
Recurrent Pregnancy Loss
Eligibility:
FEMALE
Up to 40 years
Phase:
NA
Brief Summary
In 50% of women with recurrent pregnancy loss (RPL) miscarriages are unexplained, therefore no therapeutic intervention is possible. In a pilot study, women with unexplained RPL showed less endometria...
Eligibility Criteria
Inclusion
- RPL defined as 2 or more unexplained pregnancy losses from the time of conception until 24 weeks of gestation, known cause for the miscarriages are the presence of thyroid abnormalities, anti-phospholipid syndrome, uterine malformation, and abnormal parental karyotype according to international guideline.
- Couples should not be aiming to conceive during the time course of the exercise intervention.
Exclusion
- Age above 40 years
- BMI above 40
- Current use of immunosuppressive or biological drugs
- Current use of hormone conceptive
- HIV positivity
- Current or recent (\<2 weeks) symptomatic genital infection such as chlamydia, gonorroa, or pelvic inflammatory disease
- Pre-existent diabetes mellitus, autoimmune disease or overt cardiovascular disease
- Vaccination (i.e Covid) within 1 month prior to or during sampling and intervention
- New pregnancy at time of measurements, breastfeeding
- Current or recent (\<2-3 months ago) pregnancy
- (Physical) inabilities to follow moderate aerobe cycling training
- Participants who are not capable of signing the informed consent
Key Trial Info
Start Date :
March 21 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06007560
Start Date
March 21 2022
End Date
June 1 2026
Last Update
April 6 2025
Active Locations (2)
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1
Maastricht UMC+
Maastricht, Netherlands, 6202 AZ
2
Radboud UMC
Nijmegen, Netherlands, 6500 HB