Status:
UNKNOWN
Assessing the Relationship Between Hypoxia and the Immune Environment in Myeloma Patients (CHIME)
Lead Sponsor:
The Christie NHS Foundation Trust
Conditions:
Myeloma
Eligibility:
All Genders
18+ years
Brief Summary
The study is looking at how myeloma is related to low oxygen levels (hypoxia) in the bone marrow. This is to understand the disease better. It might also guide treatment in the future. For the study,...
Eligibility Criteria
Inclusion
- 1\. Male or female patients referred to The Christie NHS Foundation Trust from another hospital with proven multiple myeloma which may be either treatment naïve or previously treated.
- 2\. Aged 18 or over 3. World Health Organisation (WHO) performance status 0 to 2 with no deterioration over the previous 2 weeks and minimum life expectancy of 12 weeks 4. Provision of written informed consent 5. Willing to undergo a bone marrow biopsy 6. Willing to take pimonidazole hydrochloride
Exclusion
- Involvement in the planning and/or conduct of the study (applies to staff at the study site)
- Evidence of any significant clinical disorder or laboratory finding that made it undesirable for the patient to participate in the study
- Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions, and requirements
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06007989
Start Date
November 1 2023
End Date
August 1 2024
Last Update
August 23 2023
Active Locations (1)
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1
The Christie NHS Foundation Trust
Manchester, Greater Manchester, United Kingdom, M20 4BX