Status:
RECRUITING
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
Lead Sponsor:
University of Virginia
Conditions:
Heart Failure, Systolic
Heart Failure, Diastolic
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacter...
Detailed Description
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Nitric oxide (NO) is a gaseous diatomic free-radical and is essential for a plethora of physiological...
Eligibility Criteria
Inclusion
- Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
- Subjects may be of either sex with age 18 years.
Exclusion
- Oral antibiotic use within previous four weeks
- Oral disease or poor oral health as determined by the Oral Health Questionnaire
- Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
- Tobacco smokers
- Pregnant or lactating females
- Hypersensitivity to any ultrasound contrast agent
- Inability to perform exercise
- Unable to communicate effectively in English to the study team.
- Diagnosis of chronic renal failure (GFR \< 60 ml/min/1.73m)
- Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol).
Key Trial Info
Start Date :
August 30 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06009276
Start Date
August 30 2023
End Date
December 1 2026
Last Update
December 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UVA Student Health and Wellness Building
Charlottesville, Virginia, United States, 22903