Status:
UNKNOWN
Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Conditions:
Weaning
Spontaneous Breathing Trial
Eligibility:
All Genders
18+ years
Brief Summary
Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. This technique is relatively invasiv...
Eligibility Criteria
Inclusion
- Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation)
- patients fulfilling criteria for an SBT
- patients will have to be able to trigger ventilator breaths with a reasonable level of assistance,
- patients with lack of severe impairment in gas exchange,
- patients that not require significant hemodynamic support.
- Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.
Exclusion
- Use of pressure support during the SBT.
- Severe hemodynamic instability (\>30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min).
- Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \< 30% predicted).
- Known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence
- Clinical judgement of the attending physician.
Key Trial Info
Start Date :
June 12 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06009731
Start Date
June 12 2023
End Date
June 1 2025
Last Update
August 24 2023
Active Locations (1)
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1
CHU Amiens
Amiens, France, 80480