Status:
RECRUITING
WHIte MAtter Hyperintensity Shape and Glymphatics
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Alzheimer Nederland
Conditions:
Cerebral Small Vessel Diseases
Dementia, Mixed
Eligibility:
All Genders
65+ years
Brief Summary
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases. ...
Detailed Description
Aim: The overall aim is to study how different pathological mechanisms in cerebral SVD influence WMH shape. Primary objective: To study the association of a more complex WMH shape with abnormalitie...
Eligibility Criteria
Inclusion
- Admitted to the memory or the geriatric clinic of the LUMC, the Alrijne Hospital Leiden or the Haga Hospital the Hague
- From 65 years of age
- Eligible for MRI
- Native-level Dutch speaker
Exclusion
- Claustrophobia
- Contraindications for MRI such as metal implants and pacemaker
- Use of benzodiazepines
- Initiated treatment with antidepressants less than 6 weeks prior to inclusion
- Not being able to provide written informed consent (assessed by the treating physician)
- Individuals that have been declared mentally incapacitated
- Other severe neurological disease besides dementia related
- Cognitive impairment due to known other neurological disease
- Previous brain surgery
Key Trial Info
Start Date :
January 18 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06010511
Start Date
January 18 2023
End Date
August 31 2027
Last Update
April 13 2025
Active Locations (1)
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1
Leiden University Medical Center
Leiden, Netherlands, 2333ZA