Status:
UNKNOWN
Relationship Between Protein Intake and ICU Skeletal Muscle Weakness
Lead Sponsor:
Tufts Medical Center
Conditions:
Atrophy of Rectus Femoris Muscle (Physical Finding)
Eligibility:
All Genders
18-50 years
Brief Summary
Muscle wasting is a common finding in critically ill patients and is associated with adverse outcomes. A good strategy for avoiding or decreasing muscle loss is adding adequate quantities of protein t...
Detailed Description
Muscle wasting is a common finding in critically ill patients and is associated with adverse outcomes. Loss of mass and function of skeletal muscles start early in the first 24 h after admission and m...
Eligibility Criteria
Inclusion
- Adult patients of both sexes, 18-50 years old with a Glasgow Coma Scale ≤ 8 and an injury severity score (ISS\>15) were admitted to our ICU within 24 hours after the injury. only well-nourished ( Modified Nutric -Score for Risk Screening = 0- 4), previously healthy subjects will be recruited.
Exclusion
- Pregnancy, Patients with BMI ≥ 35,
- Vascular insufficiency or trauma to the lower limbs,
- History of neuromuscular diseases, Prolonged immobility prior to ICU admission,
- Comorbidities (renal, hepatic, cardiac disorders, chronic obstructive pulmonary disease, and diabetic patient),
- Patients with malignant diseases or immune disorders,
- Prolonged corticosteroids (CS) or neuromuscular blocking agents (NMBA) use,
- ARDS patient (P/F ratio ≤ 200), Sepsis, Multiorgan failure.
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06012201
Start Date
September 1 2023
End Date
December 1 2023
Last Update
August 25 2023
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