Status:
UNKNOWN
DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation
Lead Sponsor:
Zhongda Hospital
Conditions:
Sepsis
Septic Shock
Eligibility:
All Genders
18-80 years
Brief Summary
Objective: To investigate the correlation between plasma levels of DDX17 and GSDMD with vascular endothelial dysfunction and prognosis of in sepsis patients. Design: A single center, prospective, obs...
Detailed Description
Data collection:Recording the population information, including name, sex, BMI, and past history. Recording disease-related information's, including diagnosis, infection site, pathogens, organ dysfunc...
Eligibility Criteria
Inclusion
- There is a potential or clear infection;
- Sequential organ failure score (SOFA score) increases by more than or equal to 2 points compared to the baseline value;
- Sign informed consent form.
Exclusion
- Age\<18 years old or\>80 years old
- pregnant women
- tumor patients
- including diseases that may be complicated with vascular endothelial damage: hypertension, acute and chronic hepatitis (hepatitis caused by virus), liver cirrhosis, PT prolongation after liver transplantation, acute myocardial infarction, chronic tubular nephritis, chronic renal insufficiency/maintenance hemodialysis, renal transplantation, interstitial pneumonia, acute pancreatitis, active phase of systemic lupus erythematosus Ulcerative colitis, Crohn's disease, HELLP syndrome.
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06013033
Start Date
September 1 2023
End Date
December 31 2025
Last Update
September 6 2023
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