Status:
RECRUITING
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome
Lead Sponsor:
Zhiming Jiang
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
Acute respiratory distress syndrome (ARDS) is a clinical syndrome caused by intrapulmonary and/or extrapulmonary causes, characterized by intractable hypoxemia. Studies have shown that the sympathetic...
Detailed Description
At present, there are few studies on Esmolol in acute respiratory distress syndrome. However, previous studies have shown that Esmolol can improve oxygenation and reduce the levels of inflammatory cyt...
Eligibility Criteria
Inclusion
- Meeting the 2012 Berlin diagnostic criteria for acute respiratory distress syndrome;
- Aged between 18-65 years (inclusive);
- 95 times/min ≤ heart rate ≤120 times/min;
- The patient needs to undergo endotracheal intubation mechanical ventilation after condition assessment;
- Obtain the informed consent of the patient or his legal representative.
Exclusion
- Bradycardia and second degree or more atrioventricular block;
- Long-term use of beta-blockers;
- Combined with emphysema, asthma and other β-blocker contraindicated diseases;
- Cardiac insufficiency (NYHA grade Ⅲ or Ⅳ);
- Pregnancy
Key Trial Info
Start Date :
February 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 30 2026
Estimated Enrollment :
178 Patients enrolled
Trial Details
Trial ID
NCT06013319
Start Date
February 20 2023
End Date
October 30 2026
Last Update
March 13 2024
Active Locations (1)
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1
Department of Intensive Care Medicine
Jinan, Shandong, China, 250014