Status:
UNKNOWN
Improving Survivorship and Health-related Quality of Life in Patients With Primary Brain Tumours
Lead Sponsor:
Royal College of Surgeons, Ireland
Collaborating Sponsors:
Beaumont Hospital
Conditions:
Hypopituitarism
Radiotherapy-Induced Hypopituitarism
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Background: Approximately 480 primary, non-pituitary, brain tumours were diagnosed in Ireland each year between 1994 and 2013. Recent developments in treatment have greatly improved survival for youn...
Detailed Description
Hypothesis Adult survivors of primary, non-pituitary brain tumours have an increased risk of hypopituitarism and experience impairments in HR-QOL and neuropsychological functioning. We hypothesise tha...
Eligibility Criteria
Inclusion
- Adults (at least 18 years old) with a history of a primary, non-pituitary brain tumour which was previously treated with radiotherapy.
- Participants must have been at least 16 years old at the time of undergoing radiotherapy.
- A minimum of one year has elapsed since radiotherapy was completed.
- Capacity and willingness to provide informed consent.
Exclusion
- Diagnosed with malignant astrocytic brain tumour with life expectancy of less than six months.
- Brain tumour infiltration of the hypothalamus or pituitary pre-operatively.
- Previously diagnosis of hypopituitarism.
- Oral glucocorticoid use within the last three months.
- Pregnant or breastfeeding women at the time of recruitment.
- Unable to provide informed consent for inclusion in this study.
- Opinion of the radiation oncology or research team that participation in the study is not in the best interest of the patient for any reason.
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06014398
Start Date
September 1 2023
End Date
September 1 2025
Last Update
August 28 2023
Active Locations (2)
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1
Beaumont Hospital
Dublin, Ireland
2
St Luke's Radiation oncology Centre, Beaumont Hopsital
Dublin, Ireland