Status:
COMPLETED
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Lead Sponsor:
Postgraduate Institute of Dental Sciences Rohtak
Conditions:
Periodontitis Chronic Generalized Severe
Gingivitis
Eligibility:
All Genders
30-65 years
Brief Summary
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth. Currently, diagnosis and monitoring ...
Detailed Description
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth. The term broadly covers both gingivi...
Eligibility Criteria
Inclusion
- Presence of ≥ 20 natural teeth
- Ability and willingness to give written informed consent
- Patients belonging to 4 groups -periodontally healthy, generalized gingivitis, generalized stage I/II periodontitis, generalized stage III/IV periodontitis
Exclusion
- • Patients with chronic inflammatory disease such as nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years
- Smokers and alcoholics
- Pregnant females
- Presence of xerostomia
- Patients with oral lesions or other contact sensitivity
- Patients suffering from autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis
- Patients with acute or chronic use of medications that cause oral dryness
- Patients undergoing radiotherapy
- Patients with Grade C periodontitis
- Having received professional periodontal treatment within the previous 12 months
- Having received antibiotic medication 3 months prior to study
- Periapical pathology or other oral inflammatory conditions
- Cognitive disability (interfering with ability to give samples)
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 15 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06016023
Start Date
September 1 2023
End Date
November 15 2024
Last Update
January 15 2025
Active Locations (1)
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1
Post Graduate Institute of Dental Sciences
Rohtak, Haryana, India, 124001