Status:
COMPLETED
The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes
Lead Sponsor:
Texas Tech University
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
The purpose of this study is to examine the effect of 4 weeks of Citrulline supplementation on macro- and microvascular function during acute hyperglycemia in middle-aged and older adults with type 2 ...
Detailed Description
Using a double-blind, randomized, placebo-controlled, and cross-over design, middle-aged and older adults with type 2 diabetes will be randomized to receive either CIT supplementation (6g/day) or plac...
Eligibility Criteria
Inclusion
- Middle-aged and older women and men between 40-75 years old
- A physician diagnosed type 2 diabetes at least 3 months ago
- Treated with an oral hypoglycemic medication
- Body mass index \< 40 kg/m2
- Systolic blood pressure \< 160 mmHg
- Sedentary (defined as \< 120 min/week of exercise)
- Not currently participating in exercise or dietary interventions for at least 2 months prior the present study and willing to abstain from participating in those strategies during the duration of this study.
Exclusion
- \< 40 years of age and \> 65 years of age
- Use of medications and/or any supplements that may affect outcome variables (such as arginine- or citrulline-containing supplements, nitrates, and nitroglycerin)
- Body mass index ≥ 40 kg/m2
- Systolic blood pressure ≥ 160 mmHg
- Recent changes in medications within 3 months
- Current smoking any tobacco use
- Type 1 diabetes, severe cardiovascular/renal/pulmonary diseases
- More than 7 alcoholic drinks/week of consumption
- Premenopausal women with an irregular menstrual cycle (oligomenorrhea) or pregnancy
Key Trial Info
Start Date :
May 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2024
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06016478
Start Date
May 1 2023
End Date
July 1 2024
Last Update
May 15 2025
Active Locations (1)
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1
TTU Kinesiology and Sport Management Building
Lubbock, Texas, United States, 79409