Status:
RECRUITING
Microelectrode Recordings From the Vagus Nerve in Awake Humans
Lead Sponsor:
University of Minnesota
Conditions:
Epilepsy
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
This Anchillary project uses a refined technique of ultrasound-guided microneurography of the human cervical vagus nerve, an approach developed by Professor Vaughan Macefield and used safely to-date i...
Eligibility Criteria
Inclusion
- The participant is greater than or equal to (≥)18 years and is less than or equal to (≤) 40 years of age
- English speaking
- Medicare covered or equivalent health insurance from a partner country
Exclusion
- Pregnant
- Smokes and is unwilling to abstain from smoking on the day of the experiment.
- Inability or unwillingness to provide written informed consent.
- Individuals with difficulty standing unassisted for 5 minutes during the tilt-table testing
- Individuals found to have a significant carotid artery plaque or intima-media thickness \> 1 mm as assessed by ultrasonography during the ultrasound-screening steps of the study visit
- Vagus nerve not visible on ultrasound
- VNS electrodes are not in a suitable location to allow for microelectrode insertion
- Any other clinical reasons deemed by the investigators
Key Trial Info
Start Date :
April 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06016686
Start Date
April 1 2024
End Date
April 1 2026
Last Update
April 22 2025
Active Locations (2)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
2
99 Commercial Road
Prahan Victoria, Australia, 3182