Status:
NOT_YET_RECRUITING
Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study
Lead Sponsor:
University of Catania
Collaborating Sponsors:
University of Roma La Sapienza
Hospital General Universitario Santa Lucia
Conditions:
Multiple Sclerosis
Eligibility:
FEMALE
18-55 years
Brief Summary
The sensation of smell is influenced by the somatosensory and chemesthetic sensati¬ons of the nose: for example, the cooling sensation of menthol or the prickle of carbon dioxide from carbonated drink...
Detailed Description
From a theoretically point of view pain in the trigeminal nerve increases the surrounding perception, including the perception of the odors. It has been shown that by using sweet food it is possible t...
Eligibility Criteria
Inclusion
- Adult women (age 18 to 55) diagnosed with multiple sclerosis using the 2017 McDonald Criteria under treatment with Disease Modifying Therapy (DMTs) with or without trigeminal concerns, or newly diagnosed with MS
Exclusion
- Chronic rhinosinusitis with and without nasal polyposis; current allergic rhinitis; other nasal issues that lead to olfactory dysfunction
- anamnestic COVID with incomplete recovery
- Neurodegenerative disorders (Parkinson, Alzheimer, Fronto-temporal Dementia, cognitive impairment and brain vascular diseases)
- History of stroke in the last three years
- Depression or any psychiatric condition
- intake of drugs with sedating side effects
- major health issues that might affect olfactory function (e.g., significant renal insufficiency, uncontrolled diabetes)
- Chronic alcoholism / drug abuse
- Severe head trauma
- Severe facial injuries
- Smoker over 20 cigarettes day or smoking from more than 15 years
Key Trial Info
Start Date :
October 30 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06020937
Start Date
October 30 2024
End Date
December 30 2026
Last Update
May 8 2024
Active Locations (1)
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1
Arianna Di Stadio
Catania, Sicily, Italy, 95121