Status:
RECRUITING
"ADE Fibrinogen/RBC" Ratio on Mortality and Outcome in Massive Transfusion Patients
Lead Sponsor:
Ankara City Hospital Bilkent
Collaborating Sponsors:
Istanbul University
Ondokuz Mayıs University
Conditions:
Massive Transfusion
Bleeding During/following Surgery
Eligibility:
All Genders
18+ years
Brief Summary
Our study focuses on the transfusion of blood and blood products in cases of major bleeding, including massive transfusion scenarios where repeated doses of packed red blood cells (PRBC), fresh frozen...
Detailed Description
Massive transfusion, defined as the transfusion of total body blood volume (10 units of erythrocyte suspension or 8 units and above in some definitions) or more within 24 hours, remains one of the gre...
Eligibility Criteria
Inclusion criteria
- Age ≥ 18
- Surgical patients who received ''Transfusion of ≥ 4 U ESs and at least one fibrinogen-containing product (FFP, fibrinogen concentrate, cryoprecipitate) within 24 hours''
- Elective or emergency surgical procedures with major bleeding. Major bleeding surgeries; cardiovascular and thoracic surgery, obstetric-gynecologic surgery, orthopedics/trauma surgery, neurosurgery, transplantation and major ENT-GIS-GUS surgeries.
- Informed Consent
- Undergoing surgery within 24 hours of massive blood transfusion
Exclusion Criteria
- Death before massive transfusion
- Death during massive transfusion
- Patients whose perioperative bleeding and transfusion data cannot be accessed in detail
- Patients with missing data or non-compliance with study protocol
- Patients who have zero ADEF/ES ratio
Key Trial Info
Start Date :
November 7 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
1679 Patients enrolled
Trial Details
Trial ID
NCT06021184
Start Date
November 7 2023
End Date
September 30 2026
Last Update
December 12 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ankara Bilkent city hospital
Ankara, çankaya, Turkey (Türkiye), 06800