Status:
UNKNOWN
Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients
Lead Sponsor:
Fujian Medical University Union Hospital
Collaborating Sponsors:
The First Affiliated Hospital of Nanchang University
The First Hospital of Putian City, Putian, Fujian
Conditions:
Ventilator-associated Lung Injury
Atelectasis
Eligibility:
All Genders
60-100 years
Phase:
NA
Brief Summary
This study was divided into two parts, taking elderly patients undergoing general anesthesia surgery as the research subjects, through factorial design: 1. It was verified that in elderly patients und...
Detailed Description
More and more people need to undergo general anesthesia surgery at least once in the lifetime, and patients who undergo general anesthesia surgery often have postoperative pulmonary complications, and...
Eligibility Criteria
Inclusion
- Elderly patients aged ≥ 60 years old who undergo laparoscopic abdominal surgery；
- Body mass index（BMI） \<30；
- American society of anesthesiologists physical status classification system（ASA）:I-III；
- When the patient inhales air before surgery, SPO2≥94%；
- The duration of the operation is 2-7 hours, and the pneumoperitoneal pressure is 10-14mmHg.
Exclusion
- Patients with acute respiratory distress syndrome or pulmonary hypertension (pulmonary systolic blood pressure ≥ 40mmHg) or bronchiectasis or lung malignant tumors
- Patients with acute respiratory infections within one month before surgery
- Patients who have undergone cardiopulmonary surgery
- Receiving invasive mechanical ventilation for more than 30min within 30 days before surgery
- Patients with peak airway pressure \> 35 cm H2O during intraoperative mechanical ventilation
- Patients with severe organic lesions of the heart such as obvious heart failure and coronary heart disease
- Patients with preoperative anemia (Hb\<10g/L)
- Patients with hypoproteinemia before surgery (albumin \< 35 g/L)
- Patients with tracheostomy and severe difficult airway
- Patients with sleep apnea syndrome
- Patients with intraoperative heavy bleeding (50% of the circulating blood volume is lost ≥ 3 hours)
- Patients with mental illness, impaired consciousness and communication disorders
- Patients who refuse to participate in this trial
Key Trial Info
Start Date :
September 28 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
304 Patients enrolled
Trial Details
Trial ID
NCT06021249
Start Date
September 28 2021
End Date
June 1 2024
Last Update
September 1 2023
Active Locations (3)
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1
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
2
The First Hospital of Putian
Putian, Fujian, China
3
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China