Status:
RECRUITING
Prenatal Sonographic Prediction of Placental Histology and Function
Lead Sponsor:
Endeavor Health
Conditions:
Pregnancy Complications
Eligibility:
FEMALE
18-60 years
Brief Summary
The purpose of this two-phase observational study is to investigate the use of ultrasonography to predict placental pathology at the time of delivery.
Detailed Description
Placenta pathology is examined at the time of delivery and can show the underlying pathophysiology of adverse pregnancy outcomes. The Amsterdam consensus has identified four primary categories of inju...
Eligibility Criteria
Inclusion
- Retrospective Phase
- Inclusion criteria:
- Patients with delivery in NorthShore University HealthSystem,
- Ultrasound available within 4 weeks of delivery with adequate placental images
- Placental pathology available
- Exclusion criteria:
- Multiple gestation
- Prospective Phase Inclusion criteria
- Exposed: Patients with singleton gestation with fetal growth restriction at 20-28 weeks with a plan to deliver at NorthShore Highland Park Hospital Evanston Hospital. Patients must have a first-trimester ultrasound (\<14 weeks) to confirm pregnancy dating available in the electronic medical record.
- Unexposed: Patients who present for routine ultrasound evaluation at 36-38 weeks with normal fetal growth with a plan to deliver at NorthShore Highland Park Hospital or NorthShore Evanston Hospital.
- Exclusion criteria:
- Exposed: Multiple gestation, major fetal anomaly
- Unexposed: Multiple gestation, history of chronic hypertension, gestational or pregestational diabetes, major fetal anomaly antiphospholipid syndrome, known thrombophilia
Exclusion
Key Trial Info
Start Date :
May 28 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
320 Patients enrolled
Trial Details
Trial ID
NCT06022458
Start Date
May 28 2024
End Date
March 1 2026
Last Update
July 31 2025
Active Locations (1)
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1
NorthShore University HealthSystem
Evanston, Illinois, United States, 60201