Status:
ENROLLING_BY_INVITATION
Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?
Lead Sponsor:
University of California, Davis
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Alzheimer Disease
Mild Cognitive Impairment
Eligibility:
All Genders
50-89 years
Brief Summary
Years before someone experiences the symptoms of Alzheimer's disease, a compound called amyloid beta (Aβ) builds up in the brain. Excess Aβ - directly or indirectly - causes many of the symptoms of Al...
Eligibility Criteria
Inclusion
- By clinician (or prior research) assessment, known to either be cognitively normal, or have mild cognitive impairment
- Known Alzheimer's biomarker status. As of 2023-JUL, this must either be an amyloid PET scan, or cerebrospinal fluid measurement of amyloid and tau levels.
- NOTE: Although this is a study of the eyes, age-typical ocular/vision complaints are permissible, so long as the the retina is thought to be healthy. This list of acceptable conditions includes most people who:
- wear glasses
- wear contacts
- use over-the-counter eye drops
- have mild cataracts (no surgery scheduled)
- had cataracts removed
- had eye muscle surgery (e.g., to correct eye misalignment)
- had eyelid surgery (blepharoplasty)
- are monitored by an ophthalmologist in case a problem with the retina develops (this is sometimes suggested for people with diabetes), but one or both retinas is/are thought to be completely healthy
Exclusion
- Pregnant women
- Prisoners
- Known \*for both eyes\* to have ocular health or vision abnormalities that are not age-typical. The list of unacceptable conditions includes most people who:
- have a special corrective lens (glasses or contact lens) prescription with a sphere greater than seven
- currently use prescription eye drops (e.g., for glaucoma)
- have/had prior surgical treatment for a retinal problem (e.g., retinal detachment that required surgery)
- have/had eye injections for age-related macular degeneration
Key Trial Info
Start Date :
September 29 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 28 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06023446
Start Date
September 29 2023
End Date
February 28 2028
Last Update
December 5 2025
Active Locations (1)
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1
University of California - Davis
Sacramento, California, United States, 95816