Status:
RECRUITING
Individualized Treatments in Adults With Relapsed/Refractory Cancers
Lead Sponsor:
Case Comprehensive Cancer Center
Collaborating Sponsors:
Florida International University
Community Foundation of Broward
Conditions:
Refractory Cancer
Relapsed Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A personalized cancer medicine approach would address therapy resistance, cancer metastasis, and limited options after standard of care is exhausted in advanced cancer participants. This approach may ...
Detailed Description
Treatment itself will not be given as part of this trial. The results of the drug sensitivity test (DST) and genomic screening will be used to inform treating physician about participant-specific drug...
Eligibility Criteria
Inclusion
- Participants aged 18 years or older at the time of enrollment on this study of any gender, race, or ethnicity.
- Patients with suspected or confirmed diagnosis of recurrent or refractory cancer with no curative treatment options.
- Participants who have undergone at least two lines of previous therapy.
- Participants who are scheduled for or have recently had biopsy or tumor excised (solid tumors) or bone marrow aspirate (blood cancers) or who have scheduled or recently had paracentesis or thoracentesis performed.
- Participants willing to have a blood draw or buccal swab done for the purposes of genetic testing.
- Participants willing to sign informed consent.
Exclusion
- Participants who do not have malignant tissue available and accessible.
- Participants for whom the amount of excised malignant tissue is not sufficient for the ex vivo drug testing and/or genetic profiling.
- Participants with newly diagnosed tumors and tumors that have high (\>90%) cure rate with safe standard therapy.
Key Trial Info
Start Date :
November 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06024603
Start Date
November 20 2023
End Date
November 1 2025
Last Update
August 7 2025
Active Locations (2)
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1
Florida International University
Miami, Florida, United States, 33199
2
Lerner College of Medicine, Cleveland Clinic Florida
Weston, Florida, United States, 33331