Status:
RECRUITING
Dead Space in Mechanical Ventilation With Constant Expiratory Flow
Lead Sponsor:
University Hospital, Antwerp
Collaborating Sponsors:
Universiteit Antwerpen
Conditions:
Mechanical Ventilation
Artificial Respiration
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Conventional continuous mandatory mechanical ventilation relies on the passive recoil of the chest wall for expiration. This results in an exponentially decreasing expiratory flow. Flow controlled ve...
Eligibility Criteria
Inclusion
- Adults \[18-70\] yrs
- General anaesthesia for elective surgery
- Arterial line, central venous line and endotracheal tube as part of standard of care
- Expected duration of controlled mechanical ventilation ≥ 60 minutes
- Supine position (0±10°)
Exclusion
- One lung ventilation
- Known pregnancy
- Increased intra-abdominal pressure (pneumoperitoneum or obesity (BMI \> 30kg/m2))
- COPD GOLD IV or home oxygen dependence
- Cardiac pacemaker, implantable cardioverter-defibrillator (ICD) or thoracic neurostimulator
- Skin lesions (e.g. injury, inflammation) at the level where the Electrical Impedance Tomography (EIT) band is to be applied
- Clinical signs of raised intracranial pressure
- Potential interference with the surgery due to the setup of the study instruments.
- Patient refusal to participate
Key Trial Info
Start Date :
July 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT06024993
Start Date
July 22 2024
End Date
April 30 2026
Last Update
January 22 2025
Active Locations (1)
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1
Antwerp University Hospital (UZA)
Edegem, Antwerp, Belgium, 2650