Status:
COMPLETED
2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension
Lead Sponsor:
Texas Tech University
Conditions:
Menopause
Hypertension
Eligibility:
FEMALE
50-70 years
Phase:
NA
Brief Summary
The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via low...
Detailed Description
Using a double-blind, randomized, placebo-controlled, and crossover design, overweight or obese postmenopausal women with elevated blood pressure (BP) or hypertension will receive CIT (6 grams/day) or...
Eligibility Criteria
Inclusion
- Postmenopausal women (defined as the absence of menstruation for at least 1 year).
- Resting systolic blood pressure 120-150 mmHg.
- Between the ages of 50 - 70 years.
- Sedentary (\< 120 minutes of exercise/week).
- Body mass index of 25 - 39.9 kg/m2.
- Fasting glucose \< 126 mg/dL and HbA1c \< 6.5%.
Exclusion
- Body mass index ≥ 40 or \< 25 kg/m2.
- Systolic blood pressure \> 150 mmHg.
- Taking more than two antihypertensive medications.
- Cardiovascular diseases, type I/II diabetes, musculoskeletal disorders, or cancer.
- Changes in hypertensive medication in the past three months.
- Began or changed hormone replacement therapy in the past 6 months.
- Current smoker.
- Heavy drinking (\> 7 alcoholic drinks/week).
- Participants on beta-blockers or other vasodilatory supplements (nitrates).
- Incorporated in a weight loss program and/or aerobic or resistance training program.
Key Trial Info
Start Date :
July 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2024
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT06025383
Start Date
July 20 2023
End Date
July 1 2024
Last Update
May 15 2025
Active Locations (1)
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1
Texas Tech University
Lubbock, Texas, United States, 79409