Status:
RECRUITING
GNT Induction Treatment in Locally Advanced NPC
Lead Sponsor:
Air Force Military Medical University, China
Conditions:
Nasopharyngeal Carcinoma
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The goal of this clinical trial is to compare overall response rate between gemcitabine, nimotuzumab and toripalimab as induction treatment and gemcitabine combined with cisplatine in paitents with lo...
Eligibility Criteria
Inclusion
- Age 18 to 75 years old.
- Pathologically or cytologically confirmed stage III-IVB nasopharyngeal keratinizing squamous cell carcinoma or non-keratinizing squamous cell carcinoma.
- Patients suitable for radical radiochemotherapy.
- ECOG PS score of 0-1.
- According to the RECIST 1.1 criteria, there is at least one measurable lesion. Basic hematological parameters are normal: white blood cell count ≥4×10\^9/L; absolute neutrophil count ≥1.5×10\^9/L; platelets ≥100×10\^9/L; hemoglobin ≥90 g/L.
- Basically normal renal function: serum creatinine ≤1.5×ULN or creatinine clearance rate (CrCl) \> 60 mL/min (using the Cockcroft-Gault formula): For females: CrCl = (140-age) x weight (kg) x 0.85 / (72 x Scr mg/dl) For males: CrCl = (140-age) x weight (kg) x 1.00 / (72 x Scr mg/dl)
- Basically normal liver function: serum total bilirubin ≤1.5×ULN; aspartate aminotransferase (AST) ≤2.5×ULN; alanine aminotransferase (ALT) ≤2.5×ULN.
- Signed written informed consent.
Exclusion
- Patients who have previously undergone immunotherapy or targeted therapy.
- Participated in any other interventional clinical trials within 30 days before screening.
- History of other malignancies (except for cured skin basal cell carcinoma).
- History of primary immunodeficiency.
- Presence of uncontrolled concurrent diseases (such as heart failure, severe lung disease, severe liver disease, mental disease, etc.).
- Known HIV infection, active viral hepatitis, or tuberculosis.
- Major surgery within 90 days before the first dose of the study drug, or planned surgery.
- Allergic to the drugs used in this protocol or their components.
- Pregnant (confirmed by blood or urine HCG tests) or breastfeeding women, or those of childbearing age unwilling or unable to take effective contraceptive measures (applicable to both male and female subjects) until at least 6 months after the last trial treatment.
- The investigator believes the subject is not suitable for this study.
- Unwilling to participate in this study or unable to sign the informed consent form.
- Live vaccinations within 30 days of dosing.
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2027
Estimated Enrollment :
228 Patients enrolled
Trial Details
Trial ID
NCT06026878
Start Date
September 1 2023
End Date
September 30 2027
Last Update
September 7 2023
Active Locations (1)
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1
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032