Status:
ENROLLING_BY_INVITATION
The Effects of taVNS on Motivation in MDD With Anhedonia
Lead Sponsor:
Anhui Medical University
Conditions:
Depression
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Study of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) intervention to improve the reward motivation and response inhibition of major depression disorder and its brain network ...
Detailed Description
Anhedonia is the core symptom of MDD, which means they have deficits in processing rewards.MDD get lesser positive feelings than healthy controls from rewards as they could not use the reward outcome ...
Eligibility Criteria
Inclusion
- Meet the criteria of depression assessed by at least two psychiatrists according to the fifth version of Diagnostic and Statistical Manual of Mental Disorders.
- The score of Hamilton Depression Rating Scale-17 is larger than 18 and the score of the Apathy Evaluation scale is lager than 37.
- Patients were taking antidepressants--Selective Serotonin Reuptake Inhibitor(SSRIs) alone.
- Age was between 18 to 60 year old. The education duration was at least 6 years.
- The vision or corrected vision was normal.
- Right handedness.
- No treatment of rTMS, transcranial direct current stimulation, or electroconvulsive therapy before.
Exclusion
- History of significant head trauma or neurological disorders.
- Alcohol or drug abuse.
- Focal brain lesions.
- History of seizure.
- First degree relative with epilepsy, significant neurological illness or head trauma, endocrine disease.
- Significant unstable medical condition.
- Recent aggression or other forms of behavioral dyscontrol.
- Left-handedness.
- Pregnancy.
- Current alcohol or drug abuse
- Inability to provide informed consent.
- Patients with contraindications or factors affecting imaging quality, such as pacemakers, cochlear implants, or hearts Cerebrovascular metal stent, and metal denture.
Key Trial Info
Start Date :
March 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06026904
Start Date
March 30 2023
End Date
September 30 2025
Last Update
June 26 2024
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032