Status:
RECRUITING
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Peking University
Conditions:
Elderly
Cancer Surgery
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal. Dexmedetomidin...
Detailed Description
Along with aging population, cancer incidence and mortality are increasing. Surgical resection remains the mainstay treatment for solid organ cancer. However, despite advances in oncology and surgery,...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Aged 60 years or older.
- Scheduled to undergo radical surgery for cancer under general anesthesia, with an expected surgical duration of 2 hours or longer.
- Required patient-controlled intravenous analgesia after surgery.
- Exclusion criteria:
- Inability to communicate preoperatively due to visual, auditory, verbal. or other reasons.
- Surgery for breast cancer or intracranial tumor.
- Preoperative severe sinus bradycardia (\<50 beats per minute), sick sinus syndrome，or second-degree or above atrioventricular block without pacemaker.
- Severe hepatic dysfunction (Child-Pugh class C).
- Severe renal dysfunction (requirement of renal replacement therapy before surgery).
- Enrolled in other clinical studies.
Exclusion
Key Trial Info
Start Date :
September 12 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2028
Estimated Enrollment :
4532 Patients enrolled
Trial Details
Trial ID
NCT06030804
Start Date
September 12 2023
End Date
October 1 2028
Last Update
July 31 2025
Active Locations (39)
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1
The First Affiliated Hospital of China University of Science and Technology
Hefei, Anhui, China, 065001
2
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Hefei, Anhui, China, 230001
3
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
4
Tsinghua University Yuquan Hospital
Beijing, Beijing Municipality, China, 100040