Status:
RECRUITING
Remote Ischemic Conditioning in Aneurysmal SAH
Lead Sponsor:
Aarhus University Hospital
Conditions:
Subarachnoid Hemorrhage, Aneurysmal
Delayed Cerebral Ischemia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage. The main question it aims t...
Detailed Description
Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most devastating types of stroke. Half of the patients die during the acute ictus, and those who survive have a poor prognosis as 20-30% are dis...
Eligibility Criteria
Inclusion
- Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA)
- Aneurysmal subarachnoid hemorrhage symptom-onset ≤ 3 days
- Aneurysm protected by clipping or coiling
- Independent in daily living before symptom onset (mRS ≤ 2)
Exclusion
- Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm
- Symptomatic vasospasm at the time of enrollment
- Previous cerebral lesion e.g. symptomatic cerebral infarction (\>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications).
- History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination
- History of deep vein thrombosis or signs of deep vein thrombosis on physical examination
- Kidney involvement or prior kidney disease with an estimated glomerular filtration rate (eGFR) below safe levels for contrast infusion in relation to CT-perfusion.
- Pregnancy (Women of child-bearing age will have serum-Humane Choriogonadotropine taken prior to final inclusion. If pregnancy cannot be ruled out,the patient can't be included. Women with a safe birth control method will be encouraged to use this method during the entire period of active treatment.)
- Concomitant other acute life-threatening medical or surgical condition
Key Trial Info
Start Date :
September 9 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06032533
Start Date
September 9 2023
End Date
November 30 2027
Last Update
October 3 2025
Active Locations (1)
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1
Department of Neurosurgery, Aarhus University Hospital
Aarhus N, Danmark, Denmark, DK-8200