Decentrialz logo
  • HIPAA Compliant
  • ISO 27001 Certified
Find Trials
About UsContact
Become a Volunteer+1 877 705 1914

Status:

RECRUITING

IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients

Lead Sponsor:

Assistance Publique - Hôpitaux de Paris

Conditions:

Acute Kidney Injury

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU. Randomized controlled trials (RCTs) comparing I...

Detailed Description

Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU. Randomized controlled trials (RCTs) comparing I...

Eligibility Criteria

Inclusion

  • Adults (\> or= 18 years old) in ICU
  • Receiving (or who have received) invasive mechanical ventilation and/or catecholamine infusion
  • Availability of both equipment IHD and CRRT (in the investigational center at the time of inclusion)
  • One of the 2 following situations 4.a: Either at least one of the 3 following complications of AKI\* (whatever the KDIGO stage): persistent severe hyperkalaemia despite medical treatment, persistent severe metabolic acidosis despite medical treatment or severe pulmonary edema due to fluid overload despite diuretic therapy 4.b: Or an AKI stage 3 of KDIGO with one of the 2 following criteria: serum urea concentration\>40mmol/L or persistence of oligo-anuria\>3 days
  • \*Definitions of these complication are provided in the main text (Section 7.1)
  • Affiliation of social security system
  • Written consent obtained from the patients (from a support person, family member or a close relative if the patient is not able to expressing and sign consent) or inclusion without initial consent in case of emergency, if the patient is not able to express his/her consent and in the absence of support person, family member or a close relative

Exclusion

  • Moribund state (patient likely to die within 24h)
  • Previous inclusion in the study
  • Subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curatorship)
  • Subject receiving state medical aid
  • Pregnancy or breastfeeding woman
  • Patient included in another research trial on AKI
  • Advanced chronic kidney disease (CKD) defined by an estimated GFR\<20 mL/min/1.73 m2
  • Presence of a drug overdose or of a dialyzable toxin that necessitates RRT (because IHD may be preferable in these conditions).
  • Presence or clinical suspicion of renal obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy or acute interstitial nephritis
  • Brain injured patients or other causes of increased intracranial pressure
  • Fulminant hepatic failure

Key Trial Info

Start Date :

October 28 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

January 28 2026

Estimated Enrollment :

1000 Patients enrolled

Trial Details

Trial ID

NCT06032884

Start Date

October 28 2023

End Date

January 28 2026

Last Update

December 5 2024

Active Locations (1)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (1 locations)

1

c 001 Avicenne Service de réanimation médico chirurgicale

Bobigny, France, 93000