Status:
UNKNOWN
Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients
Lead Sponsor:
Allergi- og Lungeklinikken, Elsinore
Conditions:
Bronchial Hyperreactivity
Eligibility:
All Genders
18+ years
Brief Summary
A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%. Impulse oscillometry (IOS) measures airway resistance and reactance, a...
Detailed Description
Asthma is a common chronic disease that is characterized by a history of variable respiratory symptoms and variable expiratory airflow limitation, and usually associated with airway hyperresponsivenes...
Eligibility Criteria
Inclusion
- Doctor diagnosed asthma (based on symptoms and at least one positive asthma test within the last 5 years (AHR; reversibility to beta2-agonist, ICS, prednisolone; peak flow variation).
- Written informed consent.
Exclusion
- patients aged less than 18 years old.
- patients with an exacerbation or lower airway infection within 1 months.
- Pulmonary function test: FEV1 (% pred.) \< 60%
- Not able to perform spirometry or body plethysmography.
- Cognitive disorders and not able to answer ACQ.
- Treated with biologics.
- Pregnancy or breastfeeding
- Short-acting beta-agonists 6 h, long-acting beta-agonists 2 days, short-acting anti-muscarinic agent 12 h, Long-acting anti-muscarinic agents 7 days, and Montelukast 3 days before methacholine challenge test (MCT).
- Comorbidity with significant influence on lung function and pulmonary symptoms eg. COPD, bronchiectasis, ischemic heart disease, heart failure, atrial fibrillation, uncontrolled hypertension (\>160/100 mmHg), lung cancer, lung resection, BMI\>40 kg/m2.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2024
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06034145
Start Date
November 1 2023
End Date
November 1 2024
Last Update
September 14 2023
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