Status:
RECRUITING
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Lead Sponsor:
Columbia University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Lumbar Spinal Stenosis
Cardiac Amyloidosis
Eligibility:
All Genders
50+ years
Brief Summary
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective. The sp...
Detailed Description
This is a multicenter, prospective cohort study aimed at facilitating identification of individuals with ATTR-CA. Investigators will identify subjects with previous LSS surgery who have evidence of TT...
Eligibility Criteria
Inclusion
- Clinically indicated spinal decompressive surgery within 20 years prior to enrollment.
- Age ≥50 years at the time of the surgery.
- Able to understand and sign the informed consent document after the nature of the study has been fully explained.
Exclusion
- The presence of any of the following excludes eligibility for enrollment in this study:
- Confirmed primary amyloidosis (AL) or secondary amyloidosis (AA).
- Known TTR amyloidosis.
- Other reason that would make the subject inappropriate for entry into this study.
Key Trial Info
Start Date :
September 19 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2028
Estimated Enrollment :
1663 Patients enrolled
Trial Details
Trial ID
NCT06034405
Start Date
September 19 2023
End Date
May 1 2028
Last Update
November 12 2025
Active Locations (6)
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1
Cedars-Sinai Medical Center
Beverly Hills, California, United States, 90211
2
Tufts Medical Center
Boston, Massachusetts, United States, 02111
3
Boston Medical Center
Boston, Massachusetts, United States, 02359
4
Mayo Clinic
Rochester, Minnesota, United States, 55905