Status:
RECRUITING
Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study
Lead Sponsor:
Oregon Health and Science University
Conditions:
Neurocognitive Disorders
Anesthesia
Eligibility:
All Genders
70-110 years
Phase:
PHASE4
Brief Summary
Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative ...
Detailed Description
Aim 1: Determine the effects of intravenous vs. inhalational anesthesia on incidence of postoperative delirium and postoperative cognitive dysfunction in older adults undergoing non-cardiac surgery. ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Men and women ≥ 70 years
- Sufficient vision and hearing to complete all tests
- Proficient in spoken and written English
- Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia
- Exclusion criteria:
- Urgent or emergent surgery
- Diagnosed dementia (or MoCA\<19)
- History of Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury
- Ongoing alcohol or substance abuse (per DSM V criteria)
- Allergy to propofol or sevoflurane
- Personal or family history of malignant hyperthermia
- Planned postoperative intubation
- Brain surgery
- Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring)
- Surgical procedure requiring general anesthetic occurring within 3 months (before or after) surgical date
- Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.
Exclusion
Key Trial Info
Start Date :
August 14 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 15 2027
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT06036095
Start Date
August 14 2023
End Date
March 15 2027
Last Update
April 8 2024
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239