Status:
COMPLETED
5 Versus 10 Units of Insulin in Hyperkalemia Management
Lead Sponsor:
Oman Medical Speciality Board
Collaborating Sponsors:
Sultan Qaboos University
Conditions:
Hyperkalemia
Potassium Imbalance
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The goal of this study is to compare 5 units of intravenous Regular insulin to 10 units of intravenous regular insulin in the management of hyperkalemia. We will measure the efficacy of these 2 doses ...
Detailed Description
Introduction: Hyperkalaemia is a serum Potassium (K) level of more than 5.5 mEq/L. It is a common emergency medicine presentation and can be life-threatening. Because of the emergency in correcting hy...
Eligibility Criteria
Inclusion
- Hyperkalemia patients with lab potassium levels equal to or more than 5.5 mEq/L (≥ 5.5 mEq/L)+.
- Adult: age 18 years or more.
- Agreed to participate in the study.
- If an investigator decides to start anti-hyperkalemia medications based on the VBG/ABG patient can be enrolled but if the main laboratory value is less than 5.5 mEq/L patients will be excluded
Exclusion
- Cardiac arrest
- Hyperglycemia with random blood sugar 20 mmol/L (13) or with acute diabetic complications like Diabetic Ketoacidosis / Hyperosmolar Hyperglycemic State.
- Hypoglycemia with random blood sugar (RBS) ≤ 3.89 mmol/l in Diabetic patients and less than 3 mmol/l in non-diabetic patients.
- Allergies for any medication in the protocol.
- Pregnancy.
- Hemolyzed potassium level as reported by the main lab.
- Hemolysis, Tumor lysis syndrome, or Rhabdomyolysis due to the ongoing release of potassium.
- Acidosis with a pH less than 7.1 will require Sodium bicarbonate (NaHO3).
- A patient who will need urgent Furosemide (Lasix), and or dialysis during the study period of 2 hours.
- Refused to participate.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2025
Estimated Enrollment :
384 Patients enrolled
Trial Details
Trial ID
NCT06036823
Start Date
October 1 2023
End Date
September 30 2025
Last Update
December 22 2025
Active Locations (1)
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1
Sultan Qaboos University hospital
Seeb, Muḩāfaz̧at Masqaţ, Oman, 123