Status:
RECRUITING
TINO: T Cells in the Nose of Older Adults
Lead Sponsor:
Leiden University Medical Center
Conditions:
Respiratory Tract Infections
Aging
Eligibility:
All Genders
18+ years
Brief Summary
Rationale: Individuals with advanced age are at a progressively increasing risk of acquiring lower respiratory tract infections. Besides calendar age, the degree of frailty also associates with increa...
Eligibility Criteria
Inclusion
- •Adults able and willing to provide informed consent.
- Specific inclusion criteria per group:
- Young adults aged 18-30 years old
- Healthy elderly aged \>65 years old
- Frail elderly \>65 years old
- Clinical Frailty score healthy elderly 1-3
- Clinical Frailty score frail elderly \>3
- Self-reported respiratory tract infection in previous year healthy elderly 0-1
- Self-reported respiratory tract infection in previous year frail elderly 0-1 or \>1
Exclusion
- Incompetence to provide informed consent prior or during study
- Current smoker or \>40 pack year history
- History of severe nose bleedings
- Diagnosed with asthma, COPD or chronic rhinosinusitis
- Use of inhalation corticosteroids or antibiotics in the past 6 weeks
- Current use of anti-coagulants (to prevent nosebleeds). Platelet inhibitors like acetylsalicylzuur (Ascal) are allowed.
- Respiratory tract infection or common cold in the past 2 weeks
- Immunocompromised individuals (with primary immune deficiency or secondary immune deficiency)
- Life expectancy \<28 days in the opinion of study physician
- Vaccination in the 2 months prior to study start. A potential subject that is only excluded from participation based on a recent vaccination will be asked to re-participate 2 months post vaccination.
Key Trial Info
Start Date :
January 24 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT06039527
Start Date
January 24 2021
End Date
May 1 2026
Last Update
September 9 2025
Active Locations (1)
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1
Leiden University Medical Center
Leiden, South Holland, Netherlands, 2333ZA