Status:
RECRUITING
Exercise Training on Brain Insulin Responsiveness
Lead Sponsor:
University Hospital Tuebingen
Conditions:
Insulin Resistance
Obesity
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will c...
Detailed Description
Investigate one acute bout of exercise on the brain insulin responsiveness using functional magnetic resonance imaging in combination with intranasal insulin in healthy participants of normal-weight a...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- BMI between ≥ 19.5 to 39 kg/m2-
- Less than 150 min/week for moderate-intensity physical activity
- Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults)
- Written consent to participate in the study
- Written consent to be informed about incidental findings
- Exclusion Criteria
- Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke
- Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, …)
- Insufficient knowledge of the German language
- Persons who cannot legally give consent
- Pregnancy or lactation
- History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures and migraines)
- Taking psychotropic drugs
- Taking medications that influence glucose metabolism
- Regular use of analgesic drugs
- Taking anticoagulant agents
- Previous bariatric surgery
- Acute infection within the last 4 weeks
- Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
- Other diseases that in the opinion of the investigator may jeopardize the success of the study or indicate a risk to the volunteer
- Current participation in a lifestyle intervention study or a pharmaceutical study
- Metal implants which cannot be removed as pacemakers, artificial heart valve, electrical devices as insulin pumps, large tattoos, retainer over more than 4 teeth, contraceptive coil, implanted magnetic metal parts as screws or plates after a surgery
- Persons with claustrophobia
- Temperature-sensitive person
- Persons with tinnitus or increased sensitivity to loud sounds
Exclusion
Key Trial Info
Start Date :
October 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06039787
Start Date
October 20 2023
End Date
December 31 2026
Last Update
November 8 2023
Active Locations (1)
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1
University Clinic Tübingen, Department of Internal Medicine IV
Tübingen, Germany, 72076